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Warren Sharp gives a detailed breakdown of two of the week's most highly-anticipated games. (Dale Zanine-USA TODAY Sport)

The Rams entered the week with a couple of injury issues in their offensive backfield and they've resolved themselves in different ways. Cam Akers missed his third straight day of practice with injured ribs on Friday. He was ruled out for Sunday's game against the Bills a short time later. Malcolm Brown had surgery to [more]

Outside linebacker Vic Beasley Jr. appears ready for his long-awaited debut with the Tennessee Titans. The man who led the NFL with 15 1/2 sacks in 2016 spent all of this year's preseason on the non-football injury list with a knee injury. Beasley finally passed his physical Sept. 5 but didn't practice for a full week until this week.

The Jets will have a very difficult matchup on the road against a talented Indianapolis Colts team in Week 3. SNY NFL Insider Ralph Vacchiano explains that for the Jets to have a chance, head coach Adam Gase needs to ditch his conservative game plan and let QB Sam Darnold sling the ball.

The banged-up 49ers look to close out their extended East Coast swing with a win over the Giants.

The Las Vegas Raiders will be without speedy rookie receiver Henry Ruggs III this week because of injuries to his knee and hamstring. Ruggs was ruled out Friday for Sunday's game against the New England Patriots, along with starting right tackle Trent Brown and linebacker Nick Kwiatkoski. Brown has been sidelined by a calf injury since leaving the opener at Carolina after one series.

Warren Sharp breaks down some of the notable Week 3 games from an analytics and betting perspective. (Brian Fluharty-USA TODAY Sports)

If the Giants are to defeat the injury-riddled San Francisco 49ers in Week 3, someone needs to step in and make up for the loss of running back Saquon Barkley. SNY NFL Insider Ralph Vacchiano points to newly acquired running back Devonta Freeman as well as Dion Lewis as potential candidates to fill that role.

Already down two wide receivers, the Jets may also be without Braxton Berrios on Sunday.

The New Orleans Saints visited with free agent cornerback Ken Crawley, who started 27 games in 42 appearances with them from 2016 to 2019.